DOI:10.1002/cac2.12535
PMID:38512765
Fasting reduces chemotherapy toxicity, enhances immunogenic tumor cell death and increases CD8+ T cell infiltration in tumors, particularly when combined with chemotherapy or immunotherapy. Moreover, fasting exhibits a sexual dimorphism in the immune system . The aim of our study was to elucidate the role of sex in the beneficial anti‐tumoral effects of combining fasting and
8(11):eabm7322.
doi: 10.1126/sciadv.abm7322.
PMID: 35294231
Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a -galactoside–binding protein, as a therapeutic target for atherosclerosis and AAA. Mice lacking Gal-1 (Lgals1−/−) developed severe atherosclerosis induced by pAAV/D377Y-mPCSK9 adenovirus and displayed higher lipid levels and lower expression of contractile markers
42(4):462-469.
doi: 10.1161/ATVBAHA.121.317346.
PMID: 35196876
Background: The goal of this study was to determine whether boosting mitochondrial respiration prevents the development of fatal aortic ruptures triggered by atherosclerosis and hypertension. Methods: Ang-II (angiotensin-II) was infused in ApoE (Apolipoprotein E)-deficient mice fed with a western diet to induce acute aortic aneurysms and lethal ruptures. Results: We found decreased mitochondrial respiration and
