15(1):e16301.
DOI: 10.15252/emmm.202216301.
PMID: 36373340
During the last decade, the stimulation of T-cell function by the blockage of immunosuppressive checkpoints has experienced an outstanding impact in the treatment of cancer. Development of the chimeric antigen receptor T-cell technology has also emerged as a powerful alternative for patients suffering from oncological processes, especially those affected by hematological neoplasms. Recent evidence suggest
DOI:10.1002/cac2.12535
PMID:38512765
Fasting reduces chemotherapy toxicity, enhances immunogenic tumor cell death and increases CD8+ T cell infiltration in tumors, particularly when combined with chemotherapy or immunotherapy. Moreover, fasting exhibits a sexual dimorphism in the immune system . The aim of our study was to elucidate the role of sex in the beneficial anti‐tumoral effects of combining fasting and
DOI: 39530590
PMID: 10.1093/cvr/cvae240
Inflammaging, characterized by persistent chronic inflammation in older adults, has emerged as a critical factor linked to age-related diseases such as cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline, which collectively contribute to the leading causes of death globally. Elevated levels of cytokines, chemokines, and others inflammatory mediators characterize inflammaging and serve as indicators of
