DOI:10.1002/cac2.12535
PMID:38512765
Fasting reduces chemotherapy toxicity, enhances immunogenic tumor cell death and increases CD8+ T cell infiltration in tumors, particularly when combined with chemotherapy or immunotherapy. Moreover, fasting exhibits a sexual dimorphism in the immune system . The aim of our study was to elucidate the role of sex in the beneficial anti‐tumoral effects of combining fasting and
DOI: 39530590
PMID: 10.1093/cvr/cvae240
Inflammaging, characterized by persistent chronic inflammation in older adults, has emerged as a critical factor linked to age-related diseases such as cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline, which collectively contribute to the leading causes of death globally. Elevated levels of cytokines, chemokines, and others inflammatory mediators characterize inflammaging and serve as indicators of
179(9):1839-1856.
doi: 10.1111/bph.15477.
PMID: 33817782 .
Metabolism is dynamically regulated to accompany immune cell function, and altered immunometabolism can result in impaired immune responses. Concomitantly, the pharmacological manipulation of metabolic processes offers an opportunity for therapeutic intervention in inflammatory disorders. The nicotinamide adenine dinucleotide (NAD+ ) is a critical metabolic intermediate that serves as enzyme cofactor in redox reactions, and is
