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Galectin-1 prevents pathological vascular remodelingin atherosclerosis and abdominal aortic aneurysm

Roldán-Montero R, Pérez-Sáez JM, Cerro-Pardo I, Oller J, Martinez-Lopez D, Nuñez E, Maller SM, Gutierrez-Muñoz C, Mendez-Barbero N, Escola-Gil JC, Michel JB, Mittelbrunn M, Vázquez J, Blanco-Colio LM, Rabinovich GA, Martin-Ventura JL.

Sci Adv. 2022 Mar;

8(11):eabm7322.
doi: 10.1126/sciadv.abm7322.
PMID: 35294231

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Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a 􀀀-galactoside–binding protein, as a therapeutic target for atherosclerosis and AAA. Mice lacking Gal-1 (Lgals1−/−) developed severe atherosclerosis induced by pAAV/D377Y-mPCSK9 adenovirus and displayed higher lipid levels and lower expression of contractile markers […]

Rewiring Vascular Metabolism Prevents Sudden Death due to Aortic Ruptures—Brief Report

Oller J, Gabandé-Rodríguez E, Roldan-Montero R, Ruiz-Rodríguez MJ, Redondo JM, Martín-Ventura JL, Mittelbrunn M.

Arterioscler Thromb Vasc Biol. 2022 Apr;

42(4):462-469.
doi: 10.1161/ATVBAHA.121.317346.
PMID: 35196876

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Background: The goal of this study was to determine whether boosting mitochondrial respiration prevents the development of fatal aortic ruptures triggered by atherosclerosis and hypertension. Methods: Ang-II (angiotensin-II) was infused in ApoE (Apolipoprotein E)-deficient mice fed with a western diet to induce acute aortic aneurysms and lethal ruptures. Results: We found decreased mitochondrial respiration and […]

The role of T cells in age-related diseases

Carrasco E, Gómez de Las Heras MM, Gabandé-Rodríguez E, Desdín-Micó G, Aranda JF, Mittelbrunn M.

Nat Rev Immunol. 2022 Feb;

22(2):97-111.
doi: 10.1038/s41577-021-00557-4.
PMID: 34099898

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Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair […]