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Everything everywhere all at once: Unraveling the waves of aging

Escrig-Larena JI, Mittelbrunn M.

Immunity. 2025 Feb;

11;58(2):276-278.

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In a recent work reported in Science, Zhang et al. untangle dynamic changes arising across aging in multiple cell populations within thirteen organs using single-cell transcriptomics and identify four distinct dynamic waves in which immune cells are the most affected

Roadmap for alleviating the manifestations of ageing in the cardiovascular system

Liberale L, Tual-Chalot S, Sedej S, Ministrini S, Georgiopoulos G, Grunewald M, Bäck M, Bochaton-Piallat M-L, Boon RA, Campos Ramos G, de Winther MPJ, Drosatos K, Evans PC, Ferguson JF, Forslund-Startceva SK, Goettsch C, Giacca M, Haendeler J, Kallikourdis M, Ketelhuth DFJ, Koenen RR, Lacolley P, Lutgens E, Maffia P, Miwa S, Monaco C, Montecucco F, Norata GD, Osto E, Richardson GD, Riksen NP, Soehnlein O, Spyridopoulos I, Van Linthout S, Vilahur G, Wentzel JJ, Andrés V, Badimon L, Benetos A, Binder CJ, Brandes RP, Crea F, Furman D, Gorbunova V, Guzik TJ, Hill JA, Lüscher TF, Mittelbrunn M, Nencioni A, Netea MG, Passos JF, Stamatelopoulos KS, Tavernarakis N, Ungvari Z, Wu JC, Kirkland JL, Camici GG, Dimmeler S, Kroemer G, Abdellatif M, Stellos K

Nat Rev Cardiol. 2025 Feb 19.

DOI: 10.1038/s41569-025-01130-5.

PMID: 39972009

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Ageing of the cardiovascular system is associated with frailty and various life-threatening diseases. As global populations grow older, age-related conditions increasingly determine healthspan and lifespan. The circulatory system not only supplies nutrients and oxygen to all tissues of the human body and removes by-products but also builds the largest interorgan communication network, thereby serving as

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

Gabandé-Rodríguez E, Soto-Heredero G, Carrasco E, Anerillas C, Escrig-Larena JI, Delgado-Pulido S, Francos-Quijorna I, Gómez de Las Heras MM, Fernández-Almeida A, Blanco EM, Winand-Osete E, Zorita V, Martínez-Cano J, Garrido A, de Cabo R, Mañes S, Gorospe M, Mittelbrunn M.

DOI: 10.1101/2024.01.26.577360
PMID:

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Neutrophils are the most abundant leukocytes in the blood, with numbers further increasing with age. Despite their essential role as a primary line of defense, neutrophils can contribute to tissue damage and age-related diseases 1 and a high neutrophil-to-lymphocyte ratio predicts all causes of mortality in the elderly 2–5. However, the precise mechanisms driving enhanced