Publications

KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging

Soto-Heredero G, Gabandé-Rodríguez E, Carrasco E, Escrig-Larena JI, Gómez de Las Heras MM, Delgado-Pulido S, Francos-Quijorna I, Blanco EM, Fernández-Almeida Á, Abia D, Rodríguez MJ, Fernández-Díaz CM, Álvarez-Flores MB, Ramírez de Molina A, Jung S, Del Sol A, Zorita V, Sánchez-Cabo F, Torroja C, Mittelbrunn M.

Nat Aging. 2025 Apr 30;

Online ahead of print.

  • PMID: 40307497
  • DOI: 10.1038/s43587-025-00855-9

Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4+ T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tissue senescence. Here, based on information provided by single-cell RNA sequencing data, we present a flow cytometry panel that allows the identification

Everything everywhere all at once: Unraveling the waves of aging

Escrig-Larena JI, Mittelbrunn M.

Immunity. 2025 Feb;

11;58(2):276-278.

In a recent work reported in Science, Zhang et al. untangle dynamic changes arising across aging in multiple cell populations within thirteen organs using single-cell transcriptomics and identify four distinct dynamic waves in which immune cells are the most affected

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

Gabandé-Rodríguez E, Soto-Heredero G, Carrasco E, Anerillas C, Escrig-Larena JI, Delgado-Pulido S, Francos-Quijorna I, Gómez de Las Heras MM, Fernández-Almeida A, Blanco EM, Winand-Osete E, Zorita V, Martínez-Cano J, Garrido A, de Cabo R, Mañes S, Gorospe M, Mittelbrunn M.

DOI: 10.1101/2024.01.26.577360
PMID:

Neutrophils are the most abundant leukocytes in the blood, with numbers further increasing with age. Despite their essential role as a primary line of defense, neutrophils can contribute to tissue damage and age-related diseases 1 and a high neutrophil-to-lymphocyte ratio predicts all causes of mortality in the elderly 2–5. However, the precise mechanisms driving enhanced