T cell control of the intestinal barrier and gut microbiota during ageing
The epithelial, microbial, and immune components of the intestinal barrier coexist in harmony to prevent undesirable inflammatory outcomes and ensure homeostasis in the host. In this review, we outline molecular mechanisms by which T cells regulate intestinal homeostasis and how the ageing-associated dysfunction of T cells could disturb host–microbiota symbiosis and the physical integrity of […]
Butyrate extends health and lifespan in mice with mitochondrial deficiency
Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. Here, to investigate strategies that alleviate mitochondrial dysfunction, we first generate a ubiquitous and tamoxifen-inducible knockout mouse model of mitochondrial transcription factor A (TFAM), a nuclear-encoded protein involved in mitochondrial DNA (mtDNA) maintenance — Tfamfl/flUbcCre-ERT2 (iTfamKO) mice. Systemic TFAM deficiency triggers mitochondrial decline in […]