This study of over 6,000 UK adults followed for more than 20 years shows that a simple blood test measuring plasma protein signatures can reveal whether individual organs are biologically “older” than their chronological age, thereby forecasting the risk of up to 45 age-related diseases decades before symptoms arise. It highlights that organs age as an interconnected system—accelerated aging in one organ often accelerates aging and disease risk in others—while the immune system’s biological age has the broadest impact on overall health. Importantly, these findings reinforce conclusions from María Mittelbrunn’s work showing that immunosenescence (aging of the immune system) drives systemic aging across the body. Although promising for personalized preventive medicine, the complexity and cost of profiling thousands of plasma proteins may delay widespread clinical adoption
