Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
Neutrophils are the most abundant leukocytes in the blood, with numbers further increasing with age. Despite their essential role as a primary line of defense, neutrophils can contribute to tissue damage and age-related diseases 1 and a high neutrophil-to-lymphocyte ratio predicts all causes of mortality in the elderly 2–5. However, the precise mechanisms driving enhanced […]