Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
Neutrophils are the most abundant leukocytes in the blood, with numbers further increasing with age. Despite their essential role as a primary line of defense, neutrophils can contribute to tissue damage and age-related diseases 1 and a high neutrophil-to-lymphocyte ratio predicts all causes of mortality in the elderly 2–5. However, the precise mechanisms driving enhanced […]
Inflammaging, a targetable pathway for preventing cardiovascular disease
Inflammaging, characterized by persistent chronic inflammation in older adults, has emerged as a critical factor linked to age-related diseases such as cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline, which collectively contribute to the leading causes of death globally. Elevated levels of cytokines, chemokines, and others inflammatory mediators characterize inflammaging and serve as indicators of […]
Warburg Effect Reshapes Tumor Immunogenicity.
Tumor cells rewire their metabolism to fulfill the demands of highly proliferative cells. This changes cellular metabolism to adapt to fuel and oxygen availability for energy production and to increase the synthesis capacity of building blocks for cell division and growth. In addition, the metabolic shift modulates the immunogenicity of the tumor cells. Recently, Mahmood […]
Sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy
Fasting reduces chemotherapy toxicity, enhances immunogenic tumor cell death and increases CD8+ T cell infiltration in tumors, particularly when combined with chemotherapy or immunotherapy. Moreover, fasting exhibits a sexual dimorphism in the immune system . The aim of our study was to elucidate the role of sex in the beneficial anti‐tumoral effects of combining fasting and […]