Aging reshapes the adaptive immune system from healer to saboteur
The classical role of adaptive immunity as a protector against external threats has expanded to include its functions in cancer surveillance, tissue repair and regeneration, and, more recently, it has emerged as a regulator of the aging process. In this Perspective, we discuss the mechanisms by which the deterioration of adaptive immunity contributes to inflammaging, […]
CD4 T cell therapy counteracts inflammaging and senescence by preserving gut barrier integrity
Healthy aging relies on a symbiotic host-microbiota relationship. The age-associated decline of the immune system can pose a threat to this delicate equilibrium. In this work, we investigated how the functional deterioration of T cells can affect host-microbiota symbiosis and gut barrier integrity and the implications of this deterioration for inflammaging, senescence, and health decline. […]
KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging
Recent studies using single-cell RNA sequencing technology have uncovered several subpopulations of CD4+ T cells that accumulate with aging. These age-associated T cells are emerging as relevant players in the onset of inflammaging and tissue senescence. Here, based on information provided by single-cell RNA sequencing data, we present a flow cytometry panel that allows the identification […]
Everything everywhere all at once: Unraveling the waves of aging
In a recent work reported in Science, Zhang et al. untangle dynamic changes arising across aging in multiple cell populations within thirteen organs using single-cell transcriptomics and identify four distinct dynamic waves in which immune cells are the most affected populations.